Clomid (Clomiphene)

Drug Information

• Brand: Clomid;
• Active substance: Clomiphene Citrate;
• Manufacturer: Sanofi, Pacific, Bruno Pharma.

Active substance Clomiphene

Clomiphene was approved for medical use in 1967. It is an ovulation inducer, listed by the WHO.

Clomiphene has a pronounced anti-estrogenic effect.

Estrogens play an important role in the conception process. This hormone:

• Stimulates the secretion of cervical mucus (the favorable environment necessary for the life, movement, and nutrition of spermatozoa);
• Stimulates the release of luteinizing hormone (LH);
• Promotes the regeneration and growth of the endometrium.

A deficiency or excess of estrogen can lead to the impossibility of ovulation, and therefore pregnancy.

Clomiphene provides a unique therapeutic effect. It does not directly affect the concentration of estrogens in the blood but affects estrogen receptors, which themselves regulate the level of the hormone.

In case of estrogen deficiency, these receptors increase their activity, while they decrease their activity with excess estrogens.

Clomid only helps to create the conditions for a natural change in the estrogen level in the female body. As a result, it is not a hormone replacement therapy drug and does not have negative effects on the female body.

Under the influence of the drug, the concentration of luteinizing and follicle-stimulating hormones temporarily increases in the female body.

This effect generally lasts 5 days, after which the concentration of these hormones decreases. But, with a probability of more than 76%, one or more follicles appear and mature, leading to an increase in estrogen concentration, thereby ultimately causing an LH surge and ovulation mid-cycle.

Indications for use

Clomid is prescribed for pathologies caused by an imbalance of female sex hormones in the body, such as:

• Absence of menstruation – amenorrhea;
• Infrequent periods – oligomenorrhea;
• Dysfunctional uterine bleeding;
• Milky nipple discharge unrelated to breastfeeding – galactorrhea;
• Low sperm count in men – oligospermia;
• Male breast enlargement – gynecomastia.

As the indications show, Clomid is also recommended for men with increased estrogen levels. In the male body, it acts identically and helps reduce the level of female sex hormones and increase testosterone.

Ways to buy Clomid

Clomid is a prescription drug sold in most city pharmacies. You can consult your doctor, undergo an examination, get a prescription, and buy pills at a pharmacy near you.

But this is not always the best method. You will have to pay for the doctor's consultation, and Clomid tablets will be quite expensive in a local pharmacy. They can be at least 3 times more expensive than in an online pharmacy.

In our online pharmacy, you can also buy Clomid, but at a much lower price. The minimization of the cost of maintaining an internet resource and direct supplies from the manufacturer make the price of Clomid online the most suitable for most people with low or average incomes. We ensure that every customer of our pharmacy has access to cheap medicines and can take care of their health without limitations.

Please compare the prices yourself and you will see that buying Clomid online from our pharmacy is more cost-effective and will not affect your budget.

Treatment regimens and dosages

For successful treatment of anovulatory infertility, Clomid is used in 5-day cycles/stages for 1-6 months (depending on the rate of ovulation onset).

The first stage of treatment begins on the 5th day of the menstrual cycle. Take 1 tablet of Clomid 50 mg daily for 5 days. After finishing the tablets, you should check for ovulation. It may start 7-18 days after the end of treatment. If it does not occur, it is best to repeat the treatment.

For the second and subsequent stages of treatment, the dose of Clomid should be increased to 100 mg per day. The regimen is repeated: start treatment on the 5th day of the menstrual cycle and continue for 10 days. Increasing the duration of treatment is necessary for longer control of estrogen receptors.

Clomid 100 mg tablets are taken for at least 2-4 cycles to evaluate the effectiveness of the drug and identify comorbidities affecting the possibility of conception.

Men with oligospermia are advised to start treatment with a minimum daily dose of Clomid 25 mg.

Tablets are taken 2-3 times a day for 3-4 months. If spermogram parameters do not show positive dynamics after one month of treatment, the dosage can be increased to 50 mg, 2-3 times a day. The total daily dose should not exceed 150 mg.

Recommendations for use

Please note that treatment starts with a minimum dose to test tolerance to Clomiphene.

• Tablets are taken daily, regardless of food, intake without missing a single dose.
• It is very important to start taking the pills from the 5th day of the menstrual cycle – neither later nor earlier.
• If menstruation is absent, start treatment on any day.

To determine the effectiveness of Clomid, after each treatment cycle, a transvaginal ultrasound is needed to check for follicle development.

If ovulation does not occur, treatment is repeated.

Missed dose

You should not miss a single dose of Clomid. If you miss a dose, you must restart the entire treatment from scratch. Taking a double or triple dose will not make any difference and may cause side effects. It is therefore necessary to carefully follow the dosage regimen.

Precautions

The use of Clomid is strictly contraindicated with the following diagnoses:

• Severe hepatic/renal failure;
• Uterine bleeding of unknown origin;
• Tumors in the pituitary gland;
• Pathological dysfunctions of the pituitary gland;
• Endometriosis.

Use of Clomid during pregnancy

Clomid is used to improve the reproductive function of males and females. But you should not use it during pregnancy. The use of the drug during pregnancy can cause miscarriage and terminate the pregnancy.

It should also be avoided during breastfeeding.

Possible side effects

The most common side effect of Clomid is reversible ovarian enlargement in women. This effect is natural in case of increased levels of female sex hormones, so it will not cause much discomfort.

Rarer symptoms include: headaches, hot flashes, abdominal discomfort/pain.

Very rarely (in less than 1% of patients), taking Clomid can cause liver inflammation, changes in blood count, and uterine bleeding.

Doctors also include the possibility of multiple ovulations and the probability of conceiving twins or triplets as side effects. However, this is not often the case.

Clomid: Interaction with other medications

Due to its specific mechanism of pharmacological action, Clomiphene does not interact with most known drugs. Treatment is carried out without specific limitations for this reason.

It should just be reminded that during treatment:

• You should give up alcohol;
• You should not take two drugs with a similar effect at the same time, for example, Clomid and Tamoxifen;
• You can use additional gonadotropic hormone medications.

Storage

Store in a dark place, out of reach of children, at a temperature not exceeding 25°C.

How to buy Clomid online?

The pricing policy of our online pharmacy is designed for the widest range of consumers. Even if you have a small income, it doesn't mean you have to deprive yourself.

Our goal is to maintain reproductive health. In conclusion, our employees do everything so that every woman and man has the opportunity to buy Clomid at a low price and does not give up hope of having a child.

We offer our customers:

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By buying Clomid online, you have the opportunity to fulfill your dream and have a child.