Champix (Varenicline tartrate)

Active ingredient: Varenicline

Drug Information

• Brand : Champix;
• Active substance : Varenicline tartrate;
• Manufacturer : Pfizer.

Champix and its drug substance Varenicline Tartrate

Champix is ​​also known by the name of its approved active ingredient, varenicline. The medication is available as tablets for oral administration. The tablets do not contain nicotine and are not addictive.

Notable effects of Champix:

• It simulates the effects of nicotine on the body and the central nervous system;
• It reduces the desire to smoke and relieves withdrawal symptoms;
• It blocks the action of nicotine in the body, you get less pleasure;
• It blocks nicotinic receptors in the brain.

Varenicline has been clinically proven to double your chances of quitting smoking and nicotine cravings.

Varenicline is safer than nicotine patches or bupropion because it does not pose a significant risk of mental problems (e.g., insomnia, aggression, or agitation).

Directions for use

Champix is ​​a new type of drug. According to the authorized indications, the drug is used:

• Stop smoking abruptly;
• Getting rid of nicotine addiction;
• As a preventative measure after quitting smoking.

Treatment regimens and dosages

The drug is available in the form of fast-dissolving tablets with different doses of varenicline:

• 0.5 mg tablets;
• 1 mg tablets.

Recommended dosage regimen for Champix:

• 0.5 mg once daily for the first 3 days;
• 0.5 mg 2 times daily on days 4-7;
• 1 mg 2 times daily from week 2-12.

Champix is ​​intended for continuous use for at least 12 weeks. At the beginning of treatment, the lowest doses are used so that the body can get used to the medication. In about 10 days, you will notice that you have less and less desire to smoke with each passing day.

Repeat treatment (another 12 weeks) may be useful for relapse prevention.

Recommendations for use

You should set a date or period to quit smoking. Write down this date and do not change it later.

Follow these guidelines and tips:

• Take the tablets at the same time each day;
• From the 4th day of treatment, take the tablet in the morning and another tablet in the evening;
• You are more likely to quit smoking if you are motivated;
• If you have kidney problems, you may need a lower dose;
• Take the tablets after meals to reduce the risk of nausea.

Combining Champix with other smoking cessation methods (e.g., counseling, smoking cessation plan, or family support) may increase the effectiveness of treatment.

Missed dose

If you forgot to take the tablet:

• Take it as soon as you remember to do so;
• Skip it if it is less than 3-4 hours until your next dose.

Precautions

Do not take Champix without consulting your doctor if you have or have had:

• Depression;
• Psychosis;
• Problems with blood vessels or the heart;
• Problems with the liver or kidneys.

This medication does not prevent weight gain associated with nicotine withdrawal.

Using Champix during pregnancy

Do not take Champix if you are planning to become pregnant, are pregnant, or are breastfeeding, unless advised by a doctor.

Possible side effects

The main adverse event reported during clinical trials of Champix was nausea, generally mild to moderate, which improved over time. Other treatment-related adverse events include:

• Dysphoria (depressed mood);
• Irritability;
• Increased heart rate;
• Pupil dilation;
• Pain in the eyes;
• Increased sensitivity to light;
• Increased appetite or weight gain;
• Problems falling and staying asleep;
• Increased frequency of urination.

Important information: During treatment, side effects may occur either due to drug use or due to nicotine withdrawal.

Varenicline: interaction with other drugs

Clinical studies have not established whether varenicline can affect or be affected by other prescription and over-the-counter medications. When taken with alcohol, varenicline may increase the risk of changes in behavior, thinking, or mood.

Storage

Store in a dry place at a temperature below 30°C, do not freeze.

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