Champix (Varenicline Tartrate)

Active ingredient: Varenicline

Drug Information

• Brand: Champix;
• Active substance: Varenicline Tartrate;
• Manufacturer: Pfizer.

Champix and its drug substance Varenicline Tartrate

Champix is also known by its approved active ingredient, varenicline. The medication is available as tablets to be taken orally. The tablets do not contain nicotine and are not addictive.

Notable effects of Champix:

• It mimics the effects of nicotine on the body and central nervous system;
• It reduces the desire to smoke and alleviates withdrawal symptoms;
• It blocks the action of nicotine in the body, so you get less pleasure;
• It blocks nicotine receptors in the brain.

Varenicline has been clinically proven to double your chances of quitting smoking and nicotine cravings.

Varenicline is safer than nicotine patches or bupropion as it does not pose a significant risk of mental problems (e.g., insomnia, aggression, or agitation).

Indications for use

Champix is a new type of medication. According to authorized indications, the drug is used for:

• Abrupt cessation of smoking;
• Getting rid of nicotine addiction;
• As a preventive measure after quitting smoking.

Treatment regimens and dosages

The drug is available as fast-dissolving tablets with different doses of varenicline:

• 0.5 mg tablets;
• 1 mg tablets.

Recommended dosing schedule for Champix:

• 0.5 mg once daily for the first 3 days;
• 0.5 mg twice daily on days 4-7;
• 1 mg twice daily from week 2-12.

Champix is intended for continuous use for at least 12 weeks. At the beginning of treatment, lower doses are used so that the body can get used to the medication. In about 10 days, you will notice that you have fewer and fewer cravings to smoke with each passing day.

Repeat treatment (an additional 12 weeks) may be useful for relapse prevention.

Recommendations for use

You must set a date or period to quit smoking. Note this date and do not change it later.

Follow these guidelines and advice:

• Take the tablets at the same time each day;
• From the 4th day of treatment, take one tablet in the morning and another in the evening;
• You are more likely to quit smoking if you are motivated;
• If you have kidney problems, a lower dose may be needed;
• Take the tablets after meals to reduce the risk of nausea.

Combining Champix with other smoking cessation methods (e.g., psychological assistance, a smoking cessation plan, or family support) can increase treatment effectiveness.

Missed dose

If you forgot to take the tablet:

• Take it as soon as you remember;
• Skip it if there are less than 3-4 hours until your next dose.

Precautions

Do not take Champix without consulting a doctor if you have or have had:

• Depression;
• Psychosis;
• Problems with blood vessels or the heart;
• Problems with the liver or kidneys.

This medication does not prevent weight gain associated with nicotine withdrawal.

Use of Champix during pregnancy

Do not take Champix if you are planning to become pregnant, are pregnant, or are breastfeeding, unless advised by a doctor.

Possible side effects

The main adverse event reported during Champix clinical trials was nausea, generally mild to moderate, which improved with time. Other adverse events of treatment include:

• Dysphoria (depressed mood);
• Irritability;
• Increased heart rate;
• Pupil dilation;
• Eye pain;
• Increased light sensitivity;
• Increased appetite or weight gain;
• Problems falling and staying asleep;
• Increased frequency of urination.

Important information: During treatment, side effects may occur either due to drug consumption or due to nicotine withdrawal.

Varenicline: interaction with other drugs

During clinical studies, it was not established whether varenicline can affect or be affected by other prescription and over-the-counter medications. With alcohol consumption, varenicline may increase the risk of changes in behavior, thinking, or mood.

Storage

Store in a dry place at a temperature below 30°C, do not freeze.

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